Do septic tank enzymes work? Always 33% In most cases 33% In some cases 33% Get Free Quotes Today! Question: Do septic tank enzymes work? Top Answer (33% of 3 votes): In most cases. Answer: Always Explanation: Yes, enzymes are what eats the solids in your tank to break down DeLaTorre Septic Answer: In some cases Explanation: Enzymatic treatment is not recommended. Bayshore Construction Get Free Quotes Today! Find Local Pros Free Septic System Installation Cost Estimates Related Questions How Much Does It Cost to Put in a Septic Tank? What is an Engineered Septic System? What is a Septic Baffle? What is a Septic Alarm? What is a septic Lid?